Research continues to demonstrate the potential of cannabidiol in helping a large number of people. One of the advantages of CBD is that it interacts with the endocannabinoid system in a way that produces very few unintended side effects. Though CBD and CBD oil has been shown to be safe for use and consumptions through many scientific studies, it poses some risks which if not understood could be dangerous. One important risk is the inhibition of the cytochrome P450 enzyme system.
The role of the cytochrome P450 enzyme system
This enzyme system is found within the liver and it is responsible for metabolizing potentially toxic substances which includes 60% of the drugs you have consumed. The system has more than 50 enzymes which process and eliminate toxins. When determining the appropriate dosages of medications, doctors will usually calculate the average amount it takes for various drugs to be processed through the cytochrome P450 system. In case there is only one drug being processed and the CYP450 system is healthy, the averages provide accurate dosage information.
Unfortunately, there are substances that can affect processing times within this system which makes drugs metabolize faster or slower than they would have on their own. In addition, if the CYP450 system is unhealthy due to liver problems or other pre-existing conditions, drugs may not metabolize as they are expected to.
CBD in the CYP450 system
Cannabidiol acts as an inhibitor in the cytochrome P450 system’s ability to metabolize certain drugs. As a result, it can lead to an increase in processing times of certain drugs. Besides CBD, there are other substances like grapefruit, watercress and St. John’s Wort which have an impact on CYP45 inhibition.
When CYP450 is inhibited, the result is a high level of certain drugs in your system at one time. These high levels can cause unwanted side effects and sometimes even an overdose. Sometimes, the inhibition of CBD on the CYP450 can result in too little of an active drug in the body that is desired for its therapeutic treatment.
This is why it is important to talk to a doctor if you are taking medication affected by cannabidiol to make sure that it is safe. If the doctor gives you the go ahead to supplement your personal care routine with CBD oil, then you should consider adjusting the dosage on your medications for safety purposes.
Drugs that interact with CBD
Drugs that are metabolized by the CYP450 system can interact with cannabidiol. The drugs that are metabolized by the system include:
- HMG CoA reductase inhibitors
- Calcium channel blockers
- HIV antivirals
- Immune modulators
- Epilepsy medications
- Beta blockers
- Angiotension II blockers
- Oral hypoglycemic agents
This list does not necessary mean that every drug in each category will interact with CBD. Furthermore, it does not include all of the potential medications impacted by cannabidiol. This is why it is necessary to talk to a medical professional before supplementing with CBD oil.
CBD interacts differently with certain drugs and the result of the interaction poses a potential risk to your health. If you are on other medications, you will need to talk to your doctor before using CBD.